The analysis of the perspective of the chemical class of derivatives of cyclic guanidino method median estimates

A. Spasov; P. Vasilev; K. Lenskaya; V. Anisimova

doi:doi:10.12737/13202

The analysis of the perspective of the chemical class of derivatives of cyclic guanidino method median estimates

Published в Journal of New Medical Technologies. eJournal · Volume 9, Issue 3, 2015 · Pages 0–0 · Rubrics: CLINICAL PICTURE AND METHODS OF TREATMENT. FUNCTIONAL AND INSTRUMENTAL DIAGNOSTICS. NEW MEDICINAL FORMS

DOI 10.12737/13202

Received: 17.09.2015 Accepted: 17.09.2015 Published: 17.09.2015 Language of publication: RUS

Authors

A. Spasov · P. Vasilev · K. Lenskaya · V. Anisimova

ABSTRACT

Antidiabetic activity of derivatives of cyclic guanidine is one of the types of pharmacological activity, which attracts many researchers because it gives the possibility to create medicines for the treatment of diabetes. Derivatives of cyclic guanidino manifeste a wide range of biological and pharmacological activity, including antibacterial, antiparasitic, antihistamines, anticonvulsants, anti-inflammatory, antihypertensive, antitumor, antiherpesvirus and antiviral against hepatitis C and B. These substances are also antiserotonin; antithrombotic and antioxidant activities. In the present work the authors study the dependence between the level of hy-poglycemic activity and basic chemical structures of cyclic guanidine derivatives by method of mathematical statistics. They identified class N9-substituted 2,3-dihydro-imidazo[1,2-a] benzimidazole as the most promising in terms of possible compounds with high hypoglycemic activity. The described direction in this work on the search of antidiabetic drugs are the most promising to create the medicines for pharmacotherapy of diabetes of the second type. However, the authors emphasized that the search of hypoglycemic and antidiabetic funds in the future allows to significantly expand by new data on the genetic basis and molecular mechanisms of pathogenesis of diabetes of the second type.

KEYWORDS

mathematical statistics median hypoglycemic activity cyclic guanidine basic chemical structure.

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Authors:

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Article

Pages:

from 0 to 0

Status:

Published

Language:

Russian

Keywords:

mathematical statistics, median, hypoglycemic activity, cyclic guanidine, basic chemical structure.

References

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