Efect of the Metabolic Therapy on Some Cellular and Humoral Immunity Indices in the Patients with Paranoid Form of Schizophrenia

A. Duraeva; S. Kiryukhina; V. Podsevatkin; S. Podsevatkina

doi:doi:10.12737/7268

Efect of the Metabolic Therapy on Some Cellular and Humoral Immunity Indices in the Patients with Paranoid Form of Schizophrenia

Published в Journal of New Medical Technologies · Volume 21, Issue 4, 2014 · Pages 48–53 · Rubrics: Clinical Picture and Methods of Treatment. Functional and Instrumental Diagnostics. New Medicinal Forms

DOI 10.12737/7268

Received: 18.12.2014 Accepted: 18.12.2014 Published: 18.12.2014 Language of publication: RUS

Authors

A. Duraeva · S. Kiryukhina · V. Podsevatkin · S. Podsevatkina

ABSTRACT

The purpose of this work was to examine the effect of metabolic therapy on the dynamics of the main psychopathological symptoms and some indicators of cellular and humoral immunity in the patients with paranoid schizophrenia. The study was conducted involving 25 patients. In the first stage, the patients received conventional psycho-pharmacotherapy. In the second step, the patients received immune corrector, antioxidant and hyperbaric oxygenation with the antipsychotics. Psychopathological status was assessed according to the severity of the major symptoms (maps of Avrutsky G. Y., Zaitsev S. G.). Immune homeostasis was assessed according to 21 index characterizing the cellular and humoral defense. Indica-tors were assessed at admission, the 20th, the 40th day of treatment. On admission, hyper-activation of T-cell level and reducing T-suppressors were observed in the patients in the immune status, as well as symptoms productive prevailed in psychopathological status. The study shown that the correction of immune disorders by means of metabolic therapy allows to accelerate the reduction of psychiatric symptoms, to reduce the frequency and severity of side effects in con-ventional pharmacotherapy. Due to the results significantly expand notions of pharmacology of antipsychotic drugs, antioxidants, immune modulators, hyperbaric oxygen.

KEYWORDS

schizophrenia metabolic therapy cellular and humoral immunity.

Information References

Authors:

Type:

Article

Pages:

from 48 to 53

Status:

Published

Language:

Russian

Keywords:

schizophrenia, metabolic therapy, cellular and humoral immunity.

References

1. Vartanyan M.E., Kolyaskina T.I., Minsker E.I. Immunologicheskie markery i ikh svyaz´ s terapevticheskoy effektivnost´yu psikhotropnykh preparatov / Novoe v immunologii i terapii psikhicheskikh zabolevaniy: sb. nauch. tr. M., 1988. S. 97-103.

2. Gamaleya N.B. Novoe v immunologii i terapii psikhicheskikh zabolevaniy. M., 1988. S. 110-114.

3. Garrabe Zh. Istoriya shizofrenii. M.-Spb.: B.i., 2000. 303 s.

4. Kolyaskina G.I., Sekirina T.P.,Androsova L.V. Izmenenie immunnogo profilya bol´nykh shizofre-niey v protsesse lecheniya. Zhurn. nevrologii i psikhiatrii im. Korsakova. 2009. T. 104. № 4. S. 39-45.

5. Kushner S.G., Maznina T.P. Klassy immunoglobulinov, obuslovlivayushchie antitimi-cheskuyu aktivnost´ syvorotki krovi v norme i pri psikhicheskoy patologii. Zhurn. nevrologii i psikhiatrii im. Korsakova. 2007. №7. S. 1014-1015.

6. Khadartsev A.A., Yashin A.A., Es´kov V.M., Agarkov N.M., Kobrinskiy B.A., Frolov M.V., Chukhraev A.M., Gondarev S.N., Khromushin V.A., Kamenev L.I., Valentinov B.G., Agarkova D.I. Informatsionnye tekhnologii v meditsine. Monografiya. Tula: TulGU, 2006. 272 s.

Доступ и загрузка

🗂 JATS XML ❝ To cite 📎 Citations

—

Views

—

Downloads

Citations

Индексируется в

Efect of the Metabolic Therapy on Some Cellular and Humoral Immunity Indices in the Patients with Paranoid Form of Schizophrenia

Confirmation

Регистрация